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Bacteriophage 여드름 해결책은 세균 박테리아 “박테리오파지”
2013-09-30 16:31:56

여드름 해결책은 세균 박테리아 “박테리오파지”


세균에 기생하면서 세균을 먹어치우는 이른바 세균박테리아인 박테리오파지(bacteriophage)가 여드름을 퇴치할 수 있는 매우 효과적인 방법이라는 연구결과가 나왔다.

영국 리즈 대학(University of Leeds)의 키스 홀랜드(Keith Holland) 박사는 피부에서 흔히 발견되는 박테리오파지가 여드름을 일으키는 박테리아를 죽인다는 사실을 알아냈다고 밝힌 것으로 BBC방송의 인터넷판이 4월 21일 보도했다.

홀랜드 박사는 박테리오파지가 함유된 젤을 개발해 임상시험을 시작할 계획이라고 밝히고 이를 피부에 대량 도포하면 여드름을 제거할 수 있을 것이라고 말했다.

박테리오파지는 자연적으로 존재하는 것이기 때문에 이를 치료제로 이용해도 해로운 부작용은 나타나지 않을 것이라고 홀랜드 박사는 밝혔다.

현재는 여드름을 유발하는 호르몬 분비량을 변화시키기 위해 특정 피임약을 투여하거나 항생제가 처방되고 있으나 피임약은 부작용이 있고 항생제는 내성 박테리아를 키울 수 있다.

미국피부학회(American Academy of Dermatology) 대변인 데브라 잴리먼(Debra Jaliman) 박사는 박테리오파지에 대한 연구는 아직 널리 행해지지 않고 있으나 이것이 여드름 치료에 돌파구를 열어 줄 수 있을 것이라고 논평했다.

영국 여드름치료지원단체(Acne Support Group, or ASG)에 따르면 여드름이 난 초등학교 학생들은 40%가 학교수업에 집중하지 못하고 20%는 결석하는 것으로 나타나고 있다. 여드름이 생긴 성인들은 83%가 자신감을 잃고 80%가 우울증에 빠지는 것으로 밝혀졌다. 

BBC news, "Gel 'will end the misery of acne',

 

Cures sought for acne


Gel 'will end the misery of acne' 

A scientist says he can develop a gel which will provide effective treatment of acne without side-effects. 
Professor Keith Holland, of the University of Leeds, said tests showed a virus commonly found on skin could kill the bacteria responsible for acne.

Dermatologists backed the research, but noted it was only at an early stage.

The findings come as a survey for the Acne Support Group showed children suffering from it were often missing out on schooling as a result.

Current treatments either have side-effects or involve antibiotics which, if used too much, create resistant strains.

Certain types of contraceptive pill are sometimes prescribed to alter hormonal levels responsible for the acne.

The Acne Support Group survey of 563 people found 40% of school children with acne suffered a loss of concentration on their studies as a result.

And 20% took time off school.

Among adults, 83% said their self-confidence was affected and 80% felt depressed because of the condition.


Professor Holland, a microbiologist at the Leeds Skin Research Centre, hopes to use a bacteria-specific virus, called a bacteriophage, which is commonly found on human skin.


Tests showed it attacked the bacteria responsible for acne, Professor Holland said.

He hopes to start clinical trials, testing the treatment on patients, in the summer.

Professor Holland said: "We are thinking of the future. We think a possible answer is the use of bacteriophage.

"We want to make a gel which contains the bacteriophage which we can put in a higher concentration on the skin."

Because it is naturally present, he believes there will not be a toxic side-effect in using it as a treatment.

Alison Dudley, of the Acne Support Group, said new therapies were needed.

The effect of acne on sufferers 
40% of schoolchildren with acne cannot concentrate on their studies 
20% of children miss school because of the condition 
83% of adults' self-confidence falls 
80% of adults suffer depression 
84% of people suffer scarring


Acne destroyed my confidence


Dark ages

"We are still in the dark ages with acne," she said.

Professor Holland does not yet have funding for the clinical trials he hopes to run.

Professor Michael Davis, of Central Connecticut State University's department of biological sciences, is carrying out similar research into the use of bacteriophage.

He said: "If you are treating bacterial diseases on the outside of people, I think they are a natural thing to use."

Dr Debra Jaliman, a spokeswoman for the American Academy of Dermatology, said there was not yet widespread research into the use of bacteriophage, but that it could be a positive development for the future.

She said: "It could be a big breakthrough. There are so many acne sufferers that it is something that is definitely needed." 

 




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